◆ Platform Introduction
Inhalation administration is a special route of drug delivery that exerts local or systemic therapeutic effects by acting directly on the respiratory system. Due to characteristics such as portability and good patient compliance, inhalation has become the most common route of administration after oral administration, gaining increasing attention and recognition.
LEWWIN PHARM has successfully established an internationally leading inhalation preparation research platform, possessing advanced inhalation administration experimental equipment and techniques, including precise aerosol dynamic inhalation systems for oronasal exposure for large and small animals, intratracheal nebulization, animal nasal instillation/spray, nasal spray administration, compressed air nebulization inhalation, etc. Combined with evaluation methods such as respiratory system pathology examination, lung function measurement, and bronchoalveolar lavage fluid biochemical analysis, it can provide non-clinical pharmacodynamics, pharmacokinetic, and safety evaluation services for inhalation preparations that comply with domestic and international regulations.
Respiratory System Structure
◆ Inhalation Administration Methods
◆ Introduction to the Precise Aerosol Dynamic Inhalation System for Oronasal Inhalation Exposure
Precise aerosol inhalation administration via oronasal exposure offers advantages such as closeness to clinical administration, no need for animal anesthesia, capability for multiple repeat dosing, ability to dose multiple animals simultaneously, and measurement of actual delivered dose to the animals. It is a commonly used administration method for non-clinical pharmacodynamics, PK, and TK submissions of inhalation preparations.
LEWWIN PHARM is currently equipped with multiple sets of precise aerosol dynamic inhalation systems for oronasal inhalation exposure for both large and small animals. Each instrument set is equipped with an aerosol generation system, administration system, sampling and detection system, control system, as well as a clean air generation system and an exhaust treatment system.
◆ Case Sharing - Inhalation Preparation Pharmacokinetic Studies
